– So occupational lungdiseases, once again, are cancers of the lungthat are somehow related to some work-related or someoccupational exposure. And I’m gonna talk about three types of occupational lung illness. And the first type ofoccupational lung disease, we’re gonna talk about iscalled asbestosis, asbestosis. And asbestosis is caused byasbestos exposure, right. And what environments does that have taken place in? Well, it can occur in– The exposure can occur in construction. So it can occur in construction. It are also welcome to, plumbers canbe to be subject to asbestos. So it can be seen in plumbers. And ultimately, it can also beseen in shipyard laborers, so people who work on theship or beings in the fleet, like that might be a clue to exposure to shipyard environment. Those are some of thefields in which you can be exposed to asbestos andwind up with asbestosis. And asbestosis is reallyimportant because it increases, it increases the risk of lung cancer, of lung cancer, primarily.And it also increasesthe risk of mesothelioma. So it increases the risk of lung cancer, and it increases the risk of mesothelioma. And I predict mesotheliomatends to earn more media recognition, but somethingthat’s really important be taken into consideration, that it’sactually lung cancer that’s most likely to arise after exposure to asbestos rather than mesothelioma. So a person exposed toasbestos is more likely to do up lung cancer than mesothelioma.So the second occupational lungdisease I’m gonna talk about is silicosis or show to silica. What studies does this occur in? Well, silicosis can beseen in sandblasters. Sandblasters. And it can also be seen in silica adolescents. To be honest, I didn’t evenknow there was such a thing as silica minors untilI explored this further. But there is such athing as silica minors. And silicosis is really, really, important because it increases the risk of tuberculosis. It increases the risk of TB. And the mechanism by whichit does this is important, and it’s interesting. So I wanted to explorethat a little bit further. Let’s see, what you see inthe orange here are little tuberculous bacilli. Okay, so those are, that’s a TB. And we know that TB ishandled by our person, right, by macrophages. So there are these big, lily-white blood corpuscle that will engulf the TB bacteria, that will engulf them, that will eat them all up, just like I’m trying to show the macrophages taking up the TB bacilli. So these are the macrophages, right, so the grey blood cells thatare responsible for protecting our form against this bacteria.And what silica revelation doesis it restraints the function of the macrophages so thatthe macrophages are no longer able to take up the TB. And so that predisposes aperson who’s been exposed to silica to developing TB infection. So the third largest type ofoccupational lung disease, I’d like to talk about issick, is sick structure, Sick Building Syndrome. These are only three types ofoccupational lung ailments. I’d really like to pointthat out that I picked three important ones, but theseare not the only ones. So Sick Building Syndrome, where do you get exposedto Sick Building Syndrome? Usually it’s seen when youhave AC or heating ventilation problems and likewise when peopleare exposed to different mold found in older buildingsor unkempt houses. So these three types ofoccupational lung maladies, actually have a common threadthat runs through them. They have a common pathogenesis. I’m gonna scroll down merely a touch. I’m gonna brought forward by backthis picture of the lung. And let’s say– For example, let’s say that weare inhaling these specks. These are particles of asbestos, called asbestos fibers.Or inhaling silica particles or mildews in Sick Building Syndrome. So we breath these particlesand they is now going they deposit into the tissue of the lungs. So that’s what I’m showing over here. It’s being lodged intothe tissue of the lungs. And really importantly, we havewhite blood cells sowed all throughout the tissue of the lung. And these white-hot blood cellswill take up any particles, any dirt specks also, any silica, any asbestos, any moldings, that maketheir direction into the lung. And that’s what I’m trying to show. I’m trying to show the whiteblood cells sort of engulfing these bad particles thatcan damage the lung.So through the engulfing, through the function of these macrophages or lily-white blood cell, they’re sort of engagingin engagement in the lung. And by their engaging inbattle in the lung, it leads to a sort of environment ofinflammation in the lung. So because they’re tryingto destroy these particles, it leads to this environmentof inflammation in the lung. And that sorenes during the course of not epoches or weeks or months, but over the course of several years, leads to the development ofscarring and of fibrosis, so that’s really important. So over the course of many years, all this inflammationthat’s present through the ongoing breath ofthese specks will lead to fibrosis of the lung. That fibrosis is what’sresponsible for the lung illnes, for the lung appearance. So rigor breathing andall the things that happen in occupational lungdisease in these three cases is due to fibrosis of the lung.So in asbestosis, silicosis, and in Sick Building Syndrome, you be brought to an end with scarringand fibrosis of the lungs. So keep in mind that theseare only three types of the many, countless, types ofoccupational lung cancers. And this is the mechanismby which they cause disease, eventually leading tofibrosis of the lungs ..